Blood coagulation factor drives arthritis pathogenesis
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چکیده
منابع مشابه
Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells
Aberrant immune responses represent the underlying cause of central nervous system (CNS) autoimmunity, including multiple sclerosis (MS). Recent evidence implicated the crosstalk between coagulation and immunity in CNS autoimmunity. Here we identify coagulation factor XII (FXII), the initiator of the intrinsic coagulation cascade and the kallikrein-kinin system, as a specific immune cell modula...
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Formation of thrombin is triggered when membrane-localized tissue factor (TF) is exposed to blood. In closed models of this process, thrombin formation displays an initiation phase (low rates of thrombin production cause platelet activation and fibrinogen clotting), a propagation phase (>95% of thrombin production occurs), and a termination phase (prothrombin activation ceases and free thrombin...
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Un nourisson de six mois a ete hospitalise dans le .,ervice de pediatrie du C.H.U. de Logmandolhe-Adham pour: deshydratation, etat septique, acidose metabolique, troubles circulatoires des membres avec gangrene de la main droite. Le syndrome de la coagulation intra-vasculaire disseminee (CID) a ete rapidernent confirme par l'etude de la erase sanguine. Soumis a un traitement par: solutes 6le...
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We recently showed that single-chain zymogen factor VII is converted to two-chain factor VIIa in an autocatalytic manner following complex formation with either cell-surface or solution-phase relipidated tissue factor apoprotein (Nakagaki, T., Foster, D. C., Berkner, K. L., and Kisiel, W. (1991) Biochemistry 30, 10819-10824). We have now performed a detailed kinetic analysis of the autoactivati...
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In analogy with the two categories of reactants which are used in the serological tests for the unusual category of macroglobulins called rheumatoid factor, two fluorescent reactants have been prepared for the detection of rheumatoid factor in situ in tissue sections: fluorescent antigen-rabbit antibody (immune) complex, in the present study, and fluorescent aggregated human gamma-globulin, in ...
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ژورنال
عنوان ژورنال: Nature Reviews Rheumatology
سال: 2014
ISSN: 1759-4790,1759-4804
DOI: 10.1038/nrrheum.2014.192